What is renal cell cancer bone metastasis?
Kidney cancer(renal cell cancer) is a most common cancer disease in adults, comprising about 3 % of cases of cancer in the world. About 200 thousand people worldwide are diagnosed with renal cell cancer each year, and about 50 thousand of them lived in China, Unfortunately, about 50% of them progress to advanced metastatic kidney cancer.
About 33% of patients with renal cell carcinoma had distant metastasis. There are still 20 to 40% of patients with distant metastasis even after nephrectomy. The most common metastatic sites are bone, soft tissue, lungs, liver, etc.
The bone metastasis of renal cell cancer causes great pain to the patients. The common metastatic sites are the proximal bones of the spine, pelvis and extremities. This metastasis is often characterized by progressive pain in the lesion area (metastatic area), especially in the nighttime. X-ray is characterized by osteolytic destruction, pathological bone fracture or spinal cord compression resulting in paraplegia.
The treatment of renal cell cancer with bone metastasis include surgical treatment, immunotherapy and targeted therapy.
Surgical treatment includes auxiliary nephrectomy and surgical treatment of bone metastases. It aims to remove lesions, reducing bone pain, and preventing pathological fractures and paraplegia. Simple bone metastases should be surgically removed and reconstructed and fixed bone defects. It including prosthetic replacement, intramedullary pin, and plate fixation. Curettage and decompression fixation should be performed for the spinal metastases with possible paraplegia.
Immunotherapy plays a role in controlling tumor recurrence after surgical resection.
Targeted therapy is an intervention treatment that aims to a cellular receptor, key genes and regulatory molecules such as biological targets, blocking the proliferation of tumor cells, to prevent tumor progression or resting, promote specific therapy of tumor cell apoptosis. The targeted therapy is currently due to a variety of malignant tumors of the new hope.
You may also intereseted another article about Type of bone fractures, Recognize broken bones.